Q1. What is not true about the pathogenesis of acne vulgaris
a) There is bacterial overgrowth in the pilosebaceous unit
b) Acne vulgaris is typically seen in the age group 30-40 years
c) Circulating and cutaneous androgens are implicated in the formation of comedones
d) Polycystic ovarian diseases can lead to the formation of acne
Answers
1) b
Acne vugaris is typically seen in the pubertal age group when hormonal changes are manifesting. The follicular epithelial cells undergo abnormal differentiation and have tight intercellular junctions. The rapid turn over decreases and cell shedding decreases. This phenomenon leads to formation of hyperkeratotic plugs called microcomedones. These microcomedones enlarge progressively to form noninflammatory, closed or open comedones
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